We are particularly interested in studying in vivo organelle dynamics underlying innate cellular physiology, with a specific focus on neuronal pathologies. We specialize in axonal transport, mitochondrial life cycle, endoplasmic reticulum dynamics, and the autophagy process in multiple neuronal types. Our goal is to expand our understanding of in vivo dynamic-based intracellular organelle quality control mechanisms through the application of pharmacodynamics. We primarily use Drosophila as the model system, but we also utilize a variety of model systems, from C. elegans to mammalian cells.